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Corus CAD Overview

The Corus CAD blood test provides information about the likelihood of obstructive CAD* at the time your blood is drawn and can help your doctor understand what may be causing your symptoms.

Corus CAD is a blood test that:

  • Integrates your age, sex, and gene expression to calculate a score. The higher the score, the higher the likelihood of having a significant narrowing or blockage in your heart arteries.
  • Takes into account cardiovascular differences between men and women in its assessment.
  • Has been validated in two clinical studies in the U.S. called PREDICT and COMPASS, with 526 and 431 patient samples, respectively.1,2
  • Provides your doctor with a score indicating the likelihood that you have a significant narrowing or blockage in your heart arteries.
  • Is simple to administer, safe, and convenient, requiring only a routine blood draw procedure.

Intended Corus CAD Patients

The Corus CAD test is intended for patients who complain of symptoms that may indicate signs of narrowed arteries in their hearts. These symptoms may occur with or without chest discomfort or shortness of breath and may include:

  • Tightness or pressure in the throat, jaw, shoulder, abdomen, back, or arm
  • Squeezing, heaviness, or burning sensation in the upper body
  • Abdominal discomfort or fullness
  • Indigestion or heartburn
  • Nausea
  • Vomiting
  • Dizziness or light-headedness
  • Palpitations or awareness of heartbeat

You should not have the Corus CAD test if you:

  • Have been previously diagnosed with a heart attack
  • Have had a previous invasive (surgical) procedure to open a blocked or narrowed artery
  • Are diabetic
  • Are currently taking steroids, immunosuppressive agents, or chemotherapeutic agents

If you think you are experiencing symptoms of obstructive CAD, talk to your doctor and ask if the Corus CAD test is right for you.

* Obstructive CAD is defined as at least one atherosclerotic plaque causing ≥50% luminal diameter stenosis in a major coronary artery (≥1.5 mm lumen diameter) as determined by invasive quantitative coronary angiography or coronary computed tomography angiography (≥2.0 mm lumen diameter).

  1. Rosenberg S, Elashoff MR, Beineke P, et al. Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients. Ann Intern Med. 2010;153:425-434.
  2. Thomas GS, Voros S, McPherson JA, et al. A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging: The COMPASS Study. Circ Cardiovasc Genet. 2013;6(2):154-162.