project: cardiodx

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REGISTRY I

REGISTRY I

Purpose:

To determine the impact of Corus CAD testing on primary care decision making around further cardiac testing.

Type:

Prospective

Size:

342 stable, non-acute patients in seven community-based primary care practices.

Key Findings:

Registry I1 found a strong association between cardiac referral rates by low (≤15) and elevated (>15) Corus CAD score groups, with only 6% (10/167) of the low Corus CAD score patients versus 70% (122/175) of the elevated Corus CAD score patients being referred for further cardiac evaluation (p<.0001). Approximately 49% of patients had a low Corus CAD score, allowing their primary care providers to focus on other causes for their symptoms. Each 10-point decrease in a patient's Corus CAD score was associated with a 14-fold decreased odds of referral for further cardiac evaluation or testing (p<.0001). In addition, patients with a low Corus CAD score had a 94% reduced odds of referral relative to patients with an elevated Corus CAD score (p<.0001).

Status:

Published, American Journal of Medical Quality (May 2014)1

Identifier:

NCT01557855


  1. Ladapo JA, Lyons H, Yau M, et al. Enhanced Assessment of Chest Pain and Related Symptoms in the Primary Care Setting Through the Use of a Novel Personalized Medicine Genomic Test: Results From a Prospective Registry Study. Am J Med Qual. 2014 May 5. [Epub ahead of print]