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Publications & Abstracts

Publications
Abstracts

An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
Voora D, Coles A, Lee K, et al.
Am Heart J. 2017;184:133-140.

A Novel Diagnostic Approach for Evaluating Suspected Coronary Artery Disease.
Boden WE.
Am J Med. 2016;129(6):557-559.

Impact of Exercise Stress Testing on Diagnostic Gene Expression in Patients With Obstructive and Nonobstructive Coronary Artery Disease.
Filsoof DM, Safford RE, Newby K, et al.
Am J Cardiol. 2015 May 15;115(10):1346-50.

Enhanced Assessment of Chest Pain and Related Symptoms in the Primary Care Setting Through the Use of a Novel Personalized Medicine Genomic Test: Results From a Prospective Registry Study
Ladapo JA, Lyons H, Yau M, et al.
Am J Med Qual. 2015;30(4):345-352.

Use of a Blood Test Incorporating Age, Sex, and Gene Expression Influences Medical Decision-Making in the Evaluation of Women Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease: Summary Results From Two Ambulatory Care Studies in Primary Care.
Ladapo JA, Herman L, Weiner BH, et al.
Menopause. 2015;22(11):1224-1230

Biological and Analytical Stability of a Peripheral Blood Gene Expression Score for Obstructive Coronary Artery Disease in the PREDICT and COMPASS Studies
Daniels SE, Beineke P, Rhees B, et al.
J Cardiovasc Transl Res. 2014;7(7):615-622.

Utility of a Genomic-based, Personalized Medicine Test in Patients Presenting With Symptoms Suggesting Coronary Artery Disease
Herman L, Froelich J, Kanelos D, et al.
J Am Board Fam Med. 2014;27:258–267.

Economic Utility of a Blood-Based Genomic Test for the Assessment of Patients With Symptoms Suggestive of Obstructive Coronary Artery Disease
Hochheiser LI, Juusola JL, Monane M, et al.
Popul Health Manag. 2014;17(5):287-96.

Cost Effectiveness of a Gene Expression Score and Myocardial Perfusion Imaging For Diagnosis of Coronary Artery Disease
Phelps CE, O’Sullivan AK, Ladapo JA, et al.
Am Heart J. 2014 May;167(5):697-706.

A Peripheral Blood Gene Expression Score is Associated With Atherosclerotic Plaque Burden and Stenosis by Cardiovascular CT-Angiography: Results From the PREDICT and COMPASS Studies
Voros S, Elashoff MR, Wingrove JA, et al.
Atherosclerosis. 2014;233(1):284-290.

Clinical Implications of Referral Bias in the Diagnostic Performance of Exercise Testing for Coronary Artery Disease
Ladapo JA, Blecker S, Elashoff MR, et al.
J Am Heart Assoc. 2013;2(6):e000505.

Use of the Corus CAD Gene Expression Test for Assessment of Obstructive Coronary Artery Disease Likelihood in Symptomatic Non-Diabetic Patients
Vargas J, Lima JAC, Kraus WE, et al.
PLoS Curr. 2013;5: ecurrents.eogt.0f04f6081905998fa92b99593478aeab. Accessed July 2015.

A Peripheral Blood Gene Expression Score is Associated With Plaque Volume and Phenotype by Intravascular Ultrasound With Radiofrequency Backscatter Analysis: Results From the ATLANTA Study.
Joshi PH, Rinehart S, Vazquez G, et al.
Cardiovasc Diagn Ther. 2013;3(1):5-14.

The Clinical Utility of Gene Expression Testing on the Diagnostic Evaluation of Patients Presenting to the Cardiologist with Symptoms of Suspected Obstructive Coronary Artery Disease: Results From the IMPACT (Investigation of a Molecular Personalized Coronary Gene Expression Test on Cardiology Practice Pattern) Trial
McPherson JA, Davis K, Yau M, et al.
Crit Pathw Cardiol. 2013;12(2):37-42

A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Non-Diabetic Patients Referred for Myocardial Perfusion Imaging: The COMPASS Study
Thomas GS, Voros S, McPherson JA, et al.
Circ Cardiovasc Genet. 2013;6(2):154-162.

A Gender-Specific Blood-Based Gene Expression Score for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
A Lansky, MR Elashoff, V Ng, J McPherson, D Lazar, WE Kraus, S Voros, R Schwartz and EJ Topol.
Am Heart J. 2012;164:320-326.

Identification of Factors Contributing to Variability in a Blood-Based Gene Expression Test
MR Elashoff, R Nuttall, PB Beineke, MH Doctolero, M Dickson, AM Johnson, SE Daniels, S Rosenberg and JA Wingrove.
PLoS ONE. 2012;7(7):e40068

Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, et al
J Cardiovasc Transl Res. 2012 Jun;5:366-374

Development of a Blood-Based Gene Expression Algorithm for Assessment of Obstructive Coronary Artery Disease in Non-diabetic Patients
MR Elashoff, JA Wingrove, P Beineke, SE Daniels, WG Tingley, S Rosenberg, S Voros, WE Kraus, GS Ginsburg, RS Schwartz, SG Ellis, N Tahirkheli, R Waksman, J McPherson, AJ Lansky and EJ Topol.
BMC Med Genomics.
2011;4:26.

Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients
S Rosenberg, M Elashoff, P Beineke, S Daniels, J Wingrove, W Tingley, P Sager, A Sehnert, M Yau, W Kraus, LK Newby, RS Schwartz, S Voros, SG Ellis, N Tahirkheli, R Waksman, J McPherson, A Lansky, ME Winn, NJ Schork, EJ Topol; and for the PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators.
Ann Intern Med.
2010;153:425–434.

Correlation of Peripheral-Blood Gene Expression With the Extent of Coronary Artery Stenosis
JA Wingrove, SE Daniels, AJ Sehnert, W Tingley, MR Elashoff, S Rosenberg, L Buellesfeld, E Grube, LK Newby, GS Ginsburg and WE Kraus.
Circ Cardiovasc Genet.
2008;1(1):31–38.

Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol
AJ Sehnert, SE Daniels, M Elashoff, et al.
J Am Coll Cardiol.
2008;52:644–651.

The following abstracts provide additional published research about the Corus CAD test, a blood test, which incorporates age, sex, and gene expression. They are provided for purposes of scientific information exchange. The content and statements in the materials represent solely the viewpoint of the authors and speakers at the date of the presentation. These statements are neither endorsed nor have been modified by CardioDx. CardioDx is not responsible for ensuring the information on this site is the most up-to-date information; new or additional scientific information may be available.

ACC 2016

An Age- and Sex-Specific Peripheral Blood Gene Expression Score Correlates with Future Cardiovascular Events: Insights from the PROMISE Trial. (pdf)
Voora D, Coles A, Lee K, et al.

ACC 2015

The Use of a Gene Expression Score Was Associated with Improved Medical Decision Making in the Evaluation of Women Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease: Summary Results from Two Ambulatory Care Studies in Primary Care (pdf)
Ladapo J, Herman L, Weiner B, et al.

ASHG 2014

Use of a Gene Expression Score in a Primary Care Setting to Evaluate African American Patients Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease (pdf)
Brown M, Smith D, Rhees B, et al.

SMDM 2014

Use of a Gene Expression Score in a Primary Care Setting to Evaluate African American Patients Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease (pdf)
Brown M, Smith D, Rhees B, et al.

Use of a Personalized Medicine, Gene Expression Score Influenced Decision Making Around Referral to Cardiology Among Female Patients Presenting to Primary Care with Symptoms Suggestive of Obstructive Coronary Artery Disease (pdf)
Ladapo J, Sharp D, Maniet B, et al.

ACMQ 2014

Use of a Personalized Medicine, Gene Expression Score Influenced Cardiology Referrals Among Patients Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease: Interim Results from the PRESET (A Registry to Evaluate Patterns of Care Associated with the Use of Corus CAD in Real World Clinical Care Settings) Registry (pdf)
Ladapo J, Sharp D, Maniet B, et al.

QCOR 2014

Improved Patterns of Diagnostic Management of Patients Using a Personalized Gene Expression Score Among Matched Cohorts of Patients Presenting to the Cardiologist with Symptoms of Suspected Obstructive Coronary Artery Disease: Results from the Understanding Clinician Utility-Cardiology Trial (pdf)
Kline L, Burkle J, Hoffman D, et al.

The Use of a Personalized Medicine, Blood-based Gene Expression Score in a Community-Based Cardiovascular Registry Enrolling Patients Presenting with Symptoms Suggestive of Obstructive Coronary Artery Disease: Interim Results from the PRESET (A Registry to Evaluate Patterns of Care Associated with the Use of Corus CAD in Real World Clinical Care Settings) Registry (pdf)
Ladapo J, Sharp D, Maniet B, et al.

ISPOR 2014

Use of a Blood-Based Gene Expression Score was Associated with Lower Diagnostic Testing Costs in Patients Presenting to the Cardiologist with Symptoms Suggestive of Obstructive Coronary Artery Disease: An Economic Analysis of the IMPACT-CARD (Investigation of a Molecular Personalized Coronary Gene Expression Test on Cardiology Practice Pattern) Trial (pdf)
McPherson J, Yau M, Juusola J, et al.

ACC 2014

Gene Expression Scores For CAD Are Stable Over One Year: Results From the COMPASS Trial (pdf)
Thomas GS, McPherson J, Rhees B, et al.

QCOR 2013

Improved Patterns for Advanced Non-Invasive Diagnostic Testing Using a Personalized Gene Expression Score Among Patients Presenting to Primary Care Clinicians With Symptoms of Suspected Obstructive Coronary Artery Disease: Results From the IMPACT-PCP (Investigation of a Molecular Personalized Coronary Gene Expression Test on Primary Care Practice Pattern) Trial (pdf)
Herman L, Conlin M, Watson P, et al.

Marked Variability in the Patterns of Care and Health Outcomes Among Patients Evaluated for Suspected Obstructive Coronary Artery Disease: Results From a Healthcare Claims Database Study of 12,129 Patients (pdf)
Ladapo J, Seare JG, Iorga SR, et al.

WHC 2013

The Use of a Personalized Gene Expression Test to Improve Decision Making in the Evaluation of Women with Suspected Coronary Artery Disease (pdf)
Conlin M, Herman L, Mouton M, et al.

A Gender-Specific Blood-Based Gene Expression Score for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial (pdf)
Lansky A, Elashoff MR, Ng V, et al.

ACC 2013

Improved Diagnostic Work-up of Patients Presenting to the Cardiologist with Symptoms of Suspected Obstructive Coronary Artery Disease: Gender Specific Results From the IMPACT (Investigation of a Molecular Personalized Coronary Gene Expression Test on Cardiology Practice Pattern) Trial (pdf)
McPherson JA, Davis K, Yau M, et al.

A Previously Validated Peripheral Blood Gene Expression Score is Primarily Influenced by Plaque Burden, Rather Than Ischemia, in 371 Patients From the COMPASS Multi-Center Study (pdf)
Voros S, Thomas G, Bateman T, et al.

SMDM 2012

Referral Bias in the Diagnostic Performance of Exercise Testing with Imaging for Coronary Artery Disease (pdf)
Ladapo JA, Blecker S, Elashoff MR, et al.

Cost Effectiveness of a Gene Expression Score and Myocardial Perfusion Imaging for Diagnosis of Coronary Artery Disease (pdf)
Phelps CE, Douglas PS, O’Sullivan A, et al.

GSA 2012

A Personalized Medicine Observational Study Using a Gene Expression Test to Evaluate Patients ≥ 65 Years Old Presenting with Symptoms of Suspected Obstructive Coronary Artery Disease (pdf)
M Conlin, L Herman, M Mouton, et al.

AHA 2012

Coronary Artery Plaque Burden and Stenosis by Cardiovascular CT Correlate with Peripheral Gene Expression in 614 Patients: Results from the PREDICT and COMPASS Studies (pdf)
S Voros, W Kraus, M Budoff, et al.

Peripheral Blood Gene Expression Reflects Differences Between Coronary Artery Calcification and Stenosis as Assessed by Coronary Artery Calcium Scanning and Ct Angiogaphy (pdf)
S Voros, M Budoff, W Kraus, et al.

Physicians’ Use of a Gene Expression Test was Associated With Increased Utilization and Medication Adherence Among Patients Prescribed Lipid-Lowering Therapy (pdf)
Parsons K, Yau M, Markward N, et al.

SGIM 2012

The Use of a Personalized Gene Expression Test to Improve Decision Making in the Evaluation of Patients with Suspected Coronary Artery Disease (pdf)
M Conlin, L Herman, M Mouton, et al.

QCOR 2012

Myocardial Perfusion Imaging has Markedly Lower Sensitivity after Accounting for Verification Bias (pdf)
M Elashoff, J Federspiel, J Ladapo, et al.

Improved Diagnostic Work-up of Patients Presenting to the Cardiologist with Symptoms of Suspected Obstructive Coronary Artery Disease: Results from the IMPACT (Investigation of a Molecular Personalized Coronary Gene Expression Test on Cardiology Practice Pattern) Trial (pdf)
J McPherson, K Davis, M Yau, et al.

ACC 2012

A Previously Validated Peripheral Gene Expression Score is Mostly Determined by Non-Calcified Plaque and Luminal Stenosis as Assessed by Quantitative, 3-Dimensional Measurements by CT Angiography in the Multi-Center, Prospective COMPASS Study (pdf)
S Voros, G Thomas, A Lansky, et al.

A Peripheral Blood Gene Expression Score for Coronary Artery Disease in Non-Diabetic Patients Indentifies Patients at Low Risk for Major Cardiovascular Events and Interventional Procedures in the next 12 months (pdf)
W Kraus, S Voros, R Schwartz, et al.

The Diagnostic Yield of Coronary Angiography Remains Low, Despite Prior Myocardial Perfusion Imaging Testing, in Patients With Suspected Obstructive Coronary Artery Disease: Results of the PREDICT (Personalized Risk Evaluation and Diagnosis In the Coronary Tree) Trial (pdf)
A Lansky, J McPherson, S Ellis, et al.

AHA 2011

The COMPASS Trial (NCT01117506): A Prospective Multi-center, Double-blind Study Assessing A Whole Blood Gene Expression Test For The Detection Of Obstructive Coronary Artery Disease In Symptomatic Patients Referred For Myocardial Perfusion Imaging (pdf)
G Thomas, S Voros, J McPherson, et al.

Validation of a Gene Expression Test Score Using Coronary Artery Calcium and CT-Angiography as Reference Standard for Plaque Burden and Stenosis Evaluation (pdf)
S Voros, MJ Budoff, MR Elashoff, et al.

ASHG 2011

Sequencing of Whole Blood Cell RNA: Duplex Specific Nuclease Treatment for Removal of Abundant RNA Species (pdf)
K Fitch, S Luo, P Beineke, et al.

ACC 2011

A Validated, Peripheral Blood Gene Expression Pattern Correlates with Coronary Arterial Plaque Burden by Quantitative Coronary Angiography and Coronary Artery Calcium Scoring (pdf)
S Voros, MR Elashoff, AJ Sehnert, et al.

A Validated Peripheral Blood Gene Expression Test Score Correlates with Plaque Volume and Components Measured by Intravascular Ultrasound with Radiofrequency Backscatter Analysis (IVUS-VH) (pdf)
PH Joshi, Z Qian, G Vazquez, et al.

PCNA 2010

Validation of a Gender-Dependent Blood-Based Gene Expression Test for Diagnosis of Obstructive Coronary Artery Disease in Non-diabetic Patients (pdf)
B Garrett, JA Wingrove, MR Elashoff, et al.

ATVB 2010

Development and Validation of a Blood-based Gene Expression Algorithm for Assessment of Obstructive Coronary Artery Disease in Nondiabetic Patients (pdf)
S Rosenberg, MR Elashoff, P Beineke, et al.

Identification of a Gene Expression Signature for Obstructive CAD in Whole Blood Using Precise Clinical Phenotyping and Paired Microarray Analysis (pdf)
JA Wingrove, MR Elashoff, P Beineke, et al.

ACC 2010

Myocardial Perfusion Imaging Performance in the PREDICT Multi-center Trial; Gender Specific Analysis and Comparison with the Corus CAD Gene Expression Score (pdf)
AJ Lansky, MR Elashoff, AJ Sehnert, et al.

AHA 2009

Development and Multi-Center Validation of a Blood-based Gene Expression Test for Diagnosis of Obstructive CAD in Non-Diabetic Patients (pdf)
WE Kraus, S Rosenberg, MR Elashoff, et al.

Impact of Promoter and 9p21 Single Nucleotide Polymorphisms on Peripheral Blood Cell Expression of Genes Responsive to Levels of Obstructive Coronary Disease (pdf)
JA Wingrove, H Tao, SE Daniels, et al.

ACC 2008

Expression Profiling of Peripheral Blood Cells Identifies Genes That Distinguish Patients With and Without Coronary Artery Stenosis (pdf)
JA Wingrove, AJ Sehnert, WG Tingley, et al.